Description

DNA-ExitusPlus™ is a novel patented reagent for the removal of nucleic acid contamination from laboratory surfaces and equipment (1). The solution employs a mild and non-corrosive chemistry for a rapid non- enzymatic degradation of nucleic acids. Already short incubation times with DNA-ExitusPlus™ completely remove unwanted DNA and RNA from work surfaces and tools (1, 2).

There are two different versions of DNA-ExitusPlus™ available: DNA-ExitusPlus™ (A7089) includes a color indicator to easily visualize the surface area covered with the reagent. DNA-ExitusPlus™ IF (A7409) is almost without color. Both solutions darken with time due to redox-active components contained in the solutions.

The unique characteristics of DNA-ExitusPlus

Catalytic and cooperative effects of the components cause a very rapid non-enzymatic, non-sequence-specific degradation of DNA and RNA molecules.

• All components of DNA-ExitusPlus are readily bio-degradable and not harmful or toxic for humans.
• No aggressive mineralic acids or alkaline substances are used. Equipment and materials are not damaged or corroded even after prolonged incubation times.
• No toxic fumes.
• Elevated temperatures above approx. 50°C speed up the reaction and the activity.

Literature

(1)  Esser, K.-H. et al. (2006) DNA decontamination: DNA-ExitusPlus in comparison with conventional reagents. Nature Methods 3, 151
(2)  Arena, A. (2010) Dna exitus plus™ versus standard bleach solution for the removal of dna contaminants on work surfaces and tools. Investigative sciences journal 2, 20-29